Blood test may help prevent overuse of antibiotics

By AFP July 7, 2016 15:30

Blood test may help prevent overuse of antibiotics

The diagnostic test, described in the peer-reviewed journal Science Translational Medicine, is being developed by the Stanford University School of Medicine in California.

“A lot of times you can’t really tell what kind of infection someone has,” said lead author Timothy Sweeney, an engineering research associate with the Stanford Institute for Immunity, Transplantation and Infection.

“If someone comes into the clinic, a bacterial or a viral infection often looks exactly the same.”

The new test, which is not yet on the market, works by identifying seven human genes whose activity changes during an infection, and whose pattern of activity can reveal whether an infection is bacterial or viral.

“Many diagnostics focus on trying to find bacteria in the bloodstream, but most infected people don’t have bloodstream infections, meaning such tests aren’t helpful,” said Sweeney.

“In contrast, our test can detect an infection anywhere in the body by ‘reading the immune system,'” he added.

“It is also significantly better — three times better — at ruling out bacterial infections compared to the next-best similar test, procalcitonin.”

The idea for such a test came after research published last year showed “a common response by the human immune system to multiple viruses that is distinct from that for bacterial infections,” said senior author Purvesh Khatri, assistant professor of medicine.

If further tests show that it works and is cost-effective, the test could be a useful tool in preventing the rise of antibiotic-resistant bacterial pathogens.

Often, patients are prescribed antibiotics because the drugs are cheap. “If we really want to make a difference, our test has to be more cost-effective than the drug itself,” said Khatri.

Drug-resistant bacteria are blamed for two million illnesses and 23,000 deaths each year in the United States. Meanwhile, as many as one in three antibiotic prescriptions written in US medical facilities is estimated to be unnecessary.

The new test must undergo trials in a clinical setting, since most of the research until now has been focused on pre-existing, online digital data sets of gene expression in various patients.

The seven-gene test was found to be accurate on blood samples from 96 critically ill children. Before the test can make it to market, it must also be incorporated into a device that can give a result in an hour or less, researchers said.

“A commercial, rapid version of the test should be into clinical trials in around 18-24 months,” said Sweeney. “Because of FDA regulations, etc., it may be a few years before it’s on the market.”




By AFP July 7, 2016 15:30

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