Mohammad Hafeez, skipper of Lahore Lions, winning the toss chose to bowl at Shaheed Veer Narayan Singh International Stadium, Raipur.
Bowlers of Lahore Lions restricted the defending champions to the total of 135 runs.
Wicket-keeper batsman Aditya Tare was the top scorer for MI with 37 runs while Michael Hussey made 28 off 26 balls.
Aizaz Cheema and Wahab Riaz took two wickets each.
Nasir Jamshed (26) and Ahmed Shehzad (34) provided Lions a 51-run stand while chasing the target of 136.
Umar Akmal, who got the Man of Match award, blasted off 38 runs hitting four 4s and two sixes in just 18 balls.
Lahore Lions will take on Northern districts in their second match which will be played on September 14 at the same venue.