The strikes were in response to repeated rocket fire by IS jihadists inside Syria on the Turkish border region of Kilis that has killed 18 people inside Turkey since the start of the year.
The state-run Anatolia news agency reported that a total of 63 IS members were killed in the drone and artillery strikes but it was not immediately possible to verify the figures.
Turkish artillery howitzers struck IS positions, killing 34 IS extremists, the report said.
Four drones took off from Turkey’s Incirlik air base, used by the US-led international coalition for air raids on the IS group, killing 29 extremists, Anatolia said.
The report did not specify which country the drones belonged to, saying they were part of the international coalition against IS. The drones struck some IS vehicles as well as five arms storage pits, it added.
Turkey’s NATO allies have sometimes lamented that Ankara could do more in the fight against IS but Turkey appears to have stepped up efforts in the last weeks after a string of attacks on its soil.
A car bomb on Sunday struck the Turkish city of Gaziantep, a major refugee hub near the Syrian border, killing at least two policemen and wounding 22 people.
Turkish media reported that investigators suspect IS, which still controls territory in Syria on the other side of the border, of carrying out the attack.
Turkey, which has been hit by a series of deadly suicide and car bombings, several of which have been blamed on IS, began air strikes against the group in Syria last summer.