The van came under the fire when polio workers were being taken to an area.
Driver Ziarat Gul was killed in the attack while a polio worker sustained injuries.
After the attack security forces cordoned off the area and initiated a search operation to capture the attackers.
Pakistan has been among the three countries in the world where polio remains endemic. The other two countries are Afghanistan and Nigeria.
The efforts to get rid of the polio virus cases have been seriously hampered by the deadly attacks on vaccination teams in Pakistan.