Washington is the only government to operate drones over Yemen but only periodically releases statements on its long-running bombing campaign against the country’s powerful Al-Qaeda branch.
Tuesday evening’s strike hit the Wadi Abida district of Marib province, east of the capital Sanaa.
The security official named one of the dead as Abu Yaqin al-Waeli, a local Al-Qaeda commander.
Marib is largely in the hands of loyalists of President Abedrabbo Mansour Hadi and his allies in a Saudi-led coalition.
But Al-Qaeda has taken advantage of fighting with the Shiite rebels who control the capital to expand their presence in the province.
Washington considers Al-Qaeda’s Yemen-based franchise to be its most dangerous and has kept up its drone war throughout the conflict.