The team management on Thursday announced its 11-member squad for the match and opted to retain the same batting side that featured in the first game against Somerset.
The management however made three changes in the bowling with only right-arm medium-fast Sohail Khan retained his spot.
Mohammad Amir and Rahat Ali will be replaced with Wahab Riaz and Imran Khan, while in the spin department, left-armer Zulfiqar Baber will come in place of leg-spinner Yasir Shah.
Pakistan arrived in Britain in June and began the tour with a two-week-long training camp at Hampshire to acclimatise to the English conditions.
Pakistan will play four Tests, five One-Day Internationals, and a Twenty20 International against England.
Pakistan team: Mohammad Hafeez, Shan Masood, Azhar Ali, Younis Khan, Misbah-ul-Haq (captain), Asad Shafiq, Sarfraz Ahmed (wicket-keeper), Wahab Riaz, Sohail Khan, Zulfiqar Babar, Imran Khan.