Pakistan rode on a brilliant 38-ball 55 from wicket-keeper batsman Mohammad Rizwan who smashed two sixes and five boundaries in the match played at the International Cricket Council academy.
All-rounder Amir Yamin struck three sixes in his 13-ball 27 while Sohaib Maqsood and opener Rafatullah Mohmand chipped in with 25 each.
For Hong Kong, paceman Haseeb Amhad was the pick of the bowlers with figures of 3-38.
Hong Kong, who have qualified for the World Twenty20 to be held in India in March and April, could not cope with the spin of Pakistan skipper Shahid Afridi (2-21) and Bilal Asif (2-13) and were bowled out for 103 in 17.1 overs.
Mark Chapman fought the lone battle for Hong Kong with a 39-ball 50 studded with two sixes and five boundaries.
Pakistan and England will play Twenty20 internationals in Dubai (November 26 and 27) and in Sharjah (November 30).