The latest blast struck before midnight on the outskirts of Pattani, one of three Muslim-majority southern provinces battered by a long-running and shadowy insurgency.
“So far there is one killed and more than 30 injured,” said Major General Thanongsak Wangsupa, Pattani provincial police commander.
“The hotel building was considerably damaged,” he told AFP.
Pictures showed fires burning on the road outside the hotel, its facade heavily damaged. Nearby a car was destroyed and karaoke bars, massage parlours and restaurants were also damaged.
Pattani is not popular with tourists, but analysts said the militants were sending a message after the string of coordinated bomb and arson attacks that struck multiple resort towns on August 11-12, leaving four dead and 37 injured.
Those attacks heightened concerns Thailand’s southern insurgency may have spread after years of stalled peace talks — a theory the country’s junta has downplayed given the importance of tourism to the economy.
Zachary Abuza, an expert on Southeast Asian militant groups, said the hotel attack was “nothing new” in insurgent tactics.
“But they’re clearly trying to send a signal that with the post Mothers’ Day bombing spree they are able to hit major urban areas,” he told AFP, referring to the tourist town attacks that fell on a Thai national holiday.
Police said in a statement that the Pattani hotel blast was preceded by a smaller bomb at a nearby bar, a so-called “double tap” tactic often adopted by insurgents. No-one was injured in the earlier blast.
A staff member at the town’s hospital said 32 people were injured, five of them critically. All are Thai nationals, the worker added, asking not to be named.