Relief activities are underway to take out the affected passengers of both vehicles for taking them to the hospitals.
The road crash took place at Pindhi-Bhattian road.
The police said that they were yet to ascertain the identity of the two female victims.
The bodies and injured were shifted to DHQ Hospital Dagar and RHC Dewana Baba.
Rescue sources said that a car collided with a motorcycle with five persons near ICI bridge in the metropolis. The deceased persons were identified as a 14-year-old boy and three-year-old Owais.
Woman killed, several people injured in Sukkur road accident.
The deceased are said to be residents of Jhang.
The Levies' vehicle met the accident when the convoy of Senator Sarfraz Bugti was moving on its way from Loralai district of Balochistan.