The shooting incident took place near Larkana-Khairpur Bridge on river Indus.
Gunmen of the Siyal clan opened fire at the members of Shaikh community involved in a land dispute with them leaving a man and his son dead on the spot.
Two other people sustained bullet injuries in the firing incident. One of the wounded succumbed to his injuries while on the way to Chandka Medical College Hospital of Larkana.
Police has filed the case and launched investigation of the incident.